DIRAS3

Across TCGA cell cohorts, DIRAS3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DIRAS3-associated genes across cancer lineages are OR4X2, LCE6A, and CST11. Each is linked with DIRAS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIRAS3-to-partner and partner-to-DIRAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by DIRAS3-low versus DIRAS3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIRAS3→partner) and Y-score (partner→DIRAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR4X2 →	+0.031	+4.981	<.001	.008	3	1
CNS	LCE6A →	+0.038	+5.754	<.001	.002	3	1
LUNG_NSCLC_LUAD	CST11 →	+0.151	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1A2 →	+0.023	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.011	+4.887	.009	.009	3	1
LUNG_NSCLC_LUAD	OR1P1 →	+0.055	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR4X2 by DIRAS3 expression — CNS

Explore this box plot interactively →