DIRAS2

Across TCGA patient cohorts, DIRAS2 mutation is significantly associated with the RNA expression of many other genes, with 2,810 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIRAS2-associated genes across cancer lineages are OR4K5, TXNL4B, and SSRP1. Each is linked with DIRAS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DIRAS2-to-partner and partner-to-DIRAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4K5 grouped by DIRAS2-low versus DIRAS2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIRAS2→partner) and Y-score (partner→DIRAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OR4K5 →	+0.049	+4.327	<.001	.009	3	3
UCEC	TXNL4B →	+0.419	+2.818	.006	.001	3	3
UCEC	SSRP1 →	+0.507	+3.375	.004	.004	3	2
UCEC	CPSF7 →	+0.406	+2.716	.001	.003	3	2
UCEC	HAUS1 →	+0.602	+3.480	.001	.002	3	2
SKCM	HOMER1 →	+0.844	+3.487	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,810 associations by consensus.

OR4K5 by DIRAS2 expression — HNSC

Explore this box plot interactively →