DIRAS1

Across TCGA patient cohorts, DIRAS1 mutation is significantly associated with the RNA expression of many other genes, with 1,325 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIRAS1-associated genes across cancer lineages are VN1R78P, YPEL5P1, and EIF1. Each is linked with DIRAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIRAS1-to-partner and partner-to-DIRAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R78P grouped by DIRAS1-low versus DIRAS1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIRAS1→partner) and Y-score (partner→DIRAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	VN1R78P →	+0.210	+5.891	<.001	<.001	3	2
CESC	YPEL5P1 →	+0.147	+5.345	<.001	.001	3	2
UCEC	EIF1 →	+0.345	+2.540	.004	.009	3	2
UCEC	RN7SL248P →	+0.060	+3.219	<.001	.004	3	2
UCEC	RNU6-33P →	+0.442	+2.036	.003	.004	3	2
HNSC	IGHD6-6 →	+1.524	+4.320	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,325 associations by consensus.

VN1R78P by DIRAS1 expression — CESC

Explore this box plot interactively →