DIO3OS

Across TCGA pan-cancer cohorts, DIO3OS RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated DIO3OS data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DIO3OS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DIO3OS expression acts as an unfavorable survival marker, although some lineages such as BRCA and ACC show a favorable association.

KIRP, BRCA, and ACC are the cancer types where DIO3OS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	II,III,IV	0.504	0.964	<.001	84	view →
BRCA	OS	Tertile	All	0.955	0.894	<.001	46	view →
ACC	DFS	Median	II,III,IV	0.763	0.395	.004	36	view →
MESO	OS	Median	II,III,IV	0.657	0.473	.006	36	view →
ESCA	OS	Tertile	III,IV	0.847	0.418	<.001	36	view →
KIRC	DFS	Tertile	II,III,IV	0.372	0.632	<.001	30	view →
LUSC	DFS	Quartile	II,III,IV	0.475	0.724	.001	25	view →
CHOL	DFS	Median	II,III,IV	0.622	0.106	.002	23	view →
CESC	DFS	Quartile	III,IV	0.338	0.795	.033	22	view →
UCS	DFS	Median	III,IV	0.593	0.249	.002	20	view →
SKCM	OS	Median	All	0.851	0.709	.007	19	view →
LIHC	DFS	Quartile	All	0.495	0.256	.012	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

DIO3OS–KIRP (OS)

Open the KIRP breakdown →