DIO3OS

Across TCGA pan-cancer cohorts, DIO3OS RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DIO3OS’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where DIO3OS RNA is repressed in tumor relative to normal tissue. In most cancer types DIO3OS is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LUAD, and KICH are the cancer types where DIO3OS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DIO3OS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−2.312	<.001	12	view →
LUAD	Female	III,IV	−1.121	<.001	11	view →
KICH	All	All	−0.640	<.001	11	view →
LUSC	Female	All	−1.132	<.001	7	view →
THCA	Male	All	−0.571	<.001	7	view →
UCEC	All	All	−2.801	<.001	6	view →
BRCA	All	II,III,IV	−1.238	<.001	6	view →
LIHC	All	All	−0.551	<.001	4	view →
STAD	Male	III,IV	−0.461	.002	4	view →
KIRP	Male	II,III,IV	−0.580	<.001	3	view →
COAD	All	All	+0.601	.038	2	view →
PRAD	All	All	−0.472	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DIO3OS–BLCA

Open the BLCA breakdown →