Across TCGA cell cohorts, DIO3 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DIO3-associated genes across cancer lineages are GFRA4, LRIT1, and HTR5A. Each is linked with DIO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIO3-to-partner and partner-to-DIO3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIO3→partner) and Y-score (partner→DIO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GFRA4 →	+0.203	+3.824	.008	.001	3	1
BLOOD_Leukemia	LRIT1 →	+0.027	+3.684	<.001	.004	3	1
BLOOD_Leukemia	HTR5A →	+0.039	+3.824	<.001	.001	3	1
BLOOD_Leukemia	OR7G3 →	+0.023	+3.969	<.001	.009	3	1
BLOOD_Leukemia	DEFB125 →	+0.028	+3.475	<.001	.006	3	1
BLOOD_Leukemia	OTOS →	+0.025	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

DIO3 survival (RNA) · tumor vs normal (RNA) · all DIO3 data types