DIO2-AS1

Across TCGA pan-cancer cohorts, DIO2-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated DIO2-AS1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DIO2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DIO2-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and DLBC show a favorable association.

UCEC, HNSC, and LIHC are the cancer types where DIO2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.685	0.865	<.001	108	view →
HNSC	OS	Median	II,III,IV	0.252	0.485	.002	39	view →
LIHC	OS	Tertile	All	0.398	0.722	<.001	36	view →
READ	DFS	Tertile	IV	0.179	0.936	.010	36	view →
ACC	DFS	Tertile	III,IV	0.048	0.362	.029	18	view →
BRCA	OS	Tertile	II,III,IV	0.976	0.951	.024	15	view →
SARC	OS	Tertile	All	0.575	0.761	.011	15	view →
LGG	DFS	Tertile	All	0.624	0.811	.002	15	view →
SKCM	DFS	Tertile	All	0.654	0.781	.020	12	view →
COAD	DFS	Tertile	III,IV	0.139	0.450	.030	6	view →
DLBC	OS	Tertile	All	1.000	0.424	.021	5	view →
OV	OS	Quartile	III,IV	0.761	0.856	.028	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

DIO2-AS1–UCEC (DFS)

Open the UCEC breakdown →