DIO2-AS1

Across TCGA pan-cancer cohorts, DIO2-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of DIO2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DIO2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types DIO2-AS1 is over-expressed in tumor, although a few such as HNSC and PAAD show the opposite, repressed pattern.

HNSC, BLCA, and PAAD are the cancer types where DIO2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DIO2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−0.358	<.001	8	view →
BLCA	All	All	+0.217	.036	2	view →
PAAD	Female	All	−0.065	.049	2	view →
BRCA	All	III,IV	−0.040	.009	2	view →
LUSC	All	All	+0.033	.025	2	view →
KIRC	All	All	−0.013	.008	2	view →
THCA	Male	IV	−0.046	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

DIO2-AS1–HNSC

Open the HNSC breakdown →