DIDO1

Across TCGA cell cohorts, DIDO1 mutation is significantly associated with the RNA expression of many other genes, with 2,628 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DIDO1-associated genes across cancer lineages are AP1AR, COPS4, and SH2D7. Each is linked with DIDO1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DIDO1-to-partner and partner-to-DIDO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP1AR grouped by DIDO1-low versus DIDO1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIDO1→partner) and Y-score (partner→DIDO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AP1AR →	+0.587	+3.380	<.001	.001	3	4
BLOOD_Leukemia	COPS4 →	+0.462	+2.463	<.001	.008	3	4
BLOOD_Leukemia	SH2D7 →	+0.069	+2.285	<.001	.006	3	4
LARGE_INTESTINE	BMPR1A →	+0.565	+2.409	.002	.003	3	3
LARGE_INTESTINE	SUFU →	+0.500	+3.541	<.001	<.001	3	3
LARGE_INTESTINE	RNF167 →	+0.349	+2.459	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,628 associations by consensus.

AP1AR by DIDO1 expression — BLOOD_Leukemia

Explore this box plot interactively →