DICER1

Across TCGA cell cohorts, DICER1 mutation is significantly associated with the RNA expression of many other genes, with 335 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DICER1-associated genes across cancer lineages are OR2B3, MTRNR2L10, and OR52N5. Each is linked with DICER1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DICER1-to-partner and partner-to-DICER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2B3 grouped by DICER1-low versus DICER1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DICER1→partner) and Y-score (partner→DICER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR2B3 →	+0.015	+4.087	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	MTRNR2L10 →	+0.151	+4.209	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	OR52N5 →	+0.020	+4.357	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	PRAMEF15 →	+0.157	+4.357	<.001	.006	3	2
LARGE_INTESTINE	MED9 →	+0.492	+3.714	.001	<.001	3	2
LARGE_INTESTINE	GID4 →	+0.573	+3.714	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 335 associations by consensus.

OR2B3 by DICER1 expression — URINARY_TRACT

Explore this box plot interactively →