DICER1-AS1

Across TCGA pan-cancer cohorts, DICER1-AS1 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated DICER1-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DICER1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DICER1-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and SKCM show a favorable association.

KIRC, MESO, and SKCM are the cancer types where DICER1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.406	0.626	<.001	69	view →
MESO	OS	Tertile	All	0.674	0.399	<.001	50	view →
SKCM	DFS	Tertile	All	0.724	0.548	<.001	48	view →
COAD	OS	Quartile	All	0.819	0.925	.003	36	view →
LGG	OS	Quartile	All	0.889	0.672	<.001	32	view →
OV	OS	Quartile	All	0.925	0.779	.004	28	view →
STAD	OS	Median	III,IV	0.531	0.712	.014	22	view →
LIHC	DFS	Tertile	III,IV	0.365	0.143	.010	22	view →
UCS	DFS	Tertile	IV	0.875	0.364	.024	20	view →
UVM	DFS	Tertile	III,IV	0.099	1.000	.002	20	view →
LUAD	DFS	Quartile	II,III,IV	0.623	0.861	.005	18	view →
PRAD	DFS	Median	All	0.665	0.892	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

DICER1-AS1–KIRC (DFS)

Open the KIRC breakdown →