DICER1-AS1

Across TCGA pan-cancer cohorts, DICER1-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DICER1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DICER1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DICER1-AS1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

COAD, THCA, and LIHC are the cancer types where DICER1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DICER1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.530	<.001	10	view →
THCA	Male	III,IV	−0.960	<.001	9	view →
LIHC	Female	II,III,IV	+0.670	<.001	8	view →
BRCA	Female	All	−0.335	<.001	6	view →
KIRC	Male	All	−0.307	<.001	6	view →
KICH	All	All	−0.679	<.001	5	view →
CHOL	All	All	+0.946	<.001	4	view →
LUAD	All	II,III,IV	−0.326	.007	3	view →
READ	Female	All	+0.797	.017	2	view →
BLCA	All	All	+0.470	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DICER1-AS1–COAD

Open the COAD breakdown →