DIAPH2-AS1

Across TCGA pan-cancer cohorts, DIAPH2-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DIAPH2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DIAPH2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DIAPH2-AS1 is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

THCA, KIRC, and COAD are the cancer types where DIAPH2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DIAPH2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	+0.127	<.001	9	view →
KIRC	Male	All	+0.085	<.001	8	view →
COAD	All	II,III,IV	+0.138	<.001	6	view →
UCEC	All	All	−0.089	.002	6	view →
LUAD	All	All	+0.340	.004	4	view →
LUSC	All	All	+0.203	<.001	4	view →
BRCA	Female	All	+0.135	.018	4	view →
KICH	All	All	−0.070	.020	3	view →
PAAD	All	All	+0.610	.002	2	view →
STAD	All	All	+0.268	.030	2	view →
CHOL	All	All	+0.244	<.001	2	view →
READ	All	All	+0.155	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DIAPH2-AS1–THCA

Open the THCA breakdown →