DIAPH1

Across TCGA pan-cancer cohorts, DIAPH1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated DIAPH1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DIAPH1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DIAPH1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where DIAPH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	1.000	0.466	.009	32	view →
CCRCC	DFS	Median	All	0.690	0.911	.002	10	view →
LUAD	DFS	Quartile	II,III,IV	0.130	0.661	.010	9	view →
HNSC	OS	Tertile	All	1.000	0.939	.024	8	view →
COAD	DFS	Median	All	0.919	0.992	.041	6	view →
GBM	OS	Median	All	0.758	0.956	.005	6	view →
LSCC	DFS	Quartile	III,IV	0.319	0.783	.031	4	view →
PDAC	OS	Tertile	IV	0.472	0.962	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

DIAPH1–UCEC (DFS)

Open the UCEC breakdown →