DIAPH1

Across TCGA patient cohorts, DIAPH1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIAPH1-associated genes across cancer lineages are JNK2, ATM, and MYH11. Each is linked with DIAPH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DIAPH1-to-partner and partner-to-DIAPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by DIAPH1-low versus DIAPH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIAPH1→partner) and Y-score (partner→DIAPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.261	+1.830	<.001	<.001	3	4
UCEC	ATM →	-0.431	-1.447	<.001	.002	3	2
SKCM	MYH11 →	-0.831	-2.000	.031	.031	3	1
SKCM	p27_pT198 →	+0.143	+2.000	.013	.031	3	1
SKCM	PARP_cleaved →	+0.227	+3.807	.001	<.001	3	1
SKCM	Smad4 →	+0.132	+2.700	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

JNK2 by DIAPH1 expression — UCEC

Explore this box plot interactively →