DIAPH1

Across TCGA cell cohorts, DIAPH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,625 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DIAPH1-associated GO terms across cancer lineages are Cell cycle checkpoint signaling, DNA replication initiation, and Replication fork processing. Each is linked with DIAPH1 in more than 11 cancer types. Because this analysis shows association rather than direction, both DIAPH1-to-partner and partner-to-DIAPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle checkpoint signaling grouped by DIAPH1-low versus DIAPH1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DIAPH1→partner) and Y-score (partner→DIAPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Cell cycle checkpoint signaling →	+0.076	+0.697	<.001	<.001	3	12
BLOOD_Myeloma	DNA replication initiation →	+0.166	+0.849	<.001	<.001	3	11
BLOOD_Myeloma	Replication fork processing →	+0.116	+0.837	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Mitotic G2/M transition checkpoint →	+0.093	+0.733	<.001	<.001	3	11
URINARY_TRACT	Cellular response to cisplatin →	+0.148	+0.601	.005	.002	3	11
BLOOD_Myeloma	Protein localization to chromosome →	+0.075	+0.987	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,625 associations by consensus.

Cell cycle checkpoint signaling by DIAPH1 expression — PANCREAS

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