DIAPH1

Across TCGA cell cohorts, DIAPH1 mutation is significantly associated with the RNA expression of many other genes, with 1,095 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DIAPH1-associated genes across cancer lineages are ATXN10, NTAN1, and PPIL6. Each is linked with DIAPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIAPH1-to-partner and partner-to-DIAPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATXN10 grouped by DIAPH1-low versus DIAPH1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIAPH1→partner) and Y-score (partner→DIAPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ATXN10 →	+0.747	+3.064	<.001	.009	3	2
LARGE_INTESTINE	NTAN1 →	+0.688	+3.169	<.001	.006	3	2
SKIN	PPIL6 →	+0.790	+3.064	<.001	.009	3	2
LARGE_INTESTINE	HINT3 →	+0.658	+3.321	.002	.003	3	2
LARGE_INTESTINE	ABHD5 →	+0.576	+2.502	<.001	.005	3	2
LARGE_INTESTINE	DPH5 →	+0.715	+2.502	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,095 associations by consensus.

ATXN10 by DIAPH1 expression — SKIN

Explore this box plot interactively →