Across TCGA patient cohorts, DIABLO RNA expression is significantly associated with the protein abundance of many other proteins, with 13,564 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DIABLO-associated proteins across cancer lineages are PRPF4B_S294, SART3, and SRSF9. Each is linked with DIABLO in more than 4 cancer types. Because this analysis shows association rather than direction, both DIABLO-to-partner and partner-to-DIABLO results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DIABLO→partner) and Y-score (partner→DIABLO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRPF4B_S294 →	+0.763	+0.380	<.001	<.001	3	5
GBM	SART3 →	+0.309	+0.334	<.001	<.001	3	5
GBM	SRSF9 →	+0.410	+0.305	<.001	<.001	3	5
GBM	BUB3 →	+0.260	+0.236	<.001	<.001	3	5
LSCC	PRPF4 →	+0.260	+0.375	<.001	<.001	3	4
GBM	ARID2 →	+0.245	+0.234	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,564 associations by consensus.

Exploration

DIABLO survival (RNA) · tumor vs normal (RNA) · all DIABLO data types