DHX9

Across TCGA patient cohorts, DHX9 mutation is significantly associated with the RNA expression of many other genes, with 5,110 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX9-associated genes across cancer lineages are RPL21P24, COX15, and BAG3. Each is linked with DHX9 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHX9-to-partner and partner-to-DHX9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL21P24 grouped by DHX9-low versus DHX9-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX9→partner) and Y-score (partner→DHX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RPL21P24 →	+0.092	+4.423	<.001	.007	3	3
UCEC	COX15 →	+0.447	+2.044	<.001	<.001	3	3
UCEC	BAG3 →	+0.403	+1.830	.003	<.001	3	3
UCEC	MPPE1 →	+0.414	+1.675	<.001	<.001	3	3
UCEC	SUPV3L1 →	+0.372	+1.642	<.001	<.001	3	3
UCEC	AP3S2 →	+0.241	+1.819	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,110 associations by consensus.

RPL21P24 by DHX9 expression — LIHC

Explore this box plot interactively →