DHX9

Across TCGA pan-cancer cohorts, DHX9 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DHX9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DHX9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DHX9 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where DHX9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHX9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.905	<.001	11	view →
COAD	All	III,IV	+0.602	<.001	10	view →
LIHC	Female	II,III,IV	+1.255	<.001	9	view →
BLCA	Female	III,IV	+0.702	<.001	9	view →
THCA	All	II,III,IV	−0.614	<.001	9	view →
STAD	Male	II,III,IV	+1.090	<.001	8	view →
LUSC	Female	All	+0.823	<.001	8	view →
KICH	Female	All	−1.437	<.001	7	view →
BRCA	All	III,IV	+0.548	<.001	6	view →
CHOL	Male	All	+2.563	<.001	5	view →
LUAD	Male	All	+0.566	<.001	5	view →
READ	All	III,IV	+1.214	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DHX9–HNSC

Open the HNSC breakdown →