DHX9

Across TCGA patient cohorts, DHX9 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX9-associated genes across cancer lineages are PCNA, 4E-BP1, and NF2. Each is linked with DHX9 in more than 3 cancer types. Because this analysis shows association rather than direction, both DHX9-to-partner and partner-to-DHX9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DHX9-low versus DHX9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX9→partner) and Y-score (partner→DHX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.163	+1.440	.012	.022	3	3
BLCA	4E-BP1 →	+0.408	+2.824	.005	.036	3	2
COAD	NF2 →	+0.218	+3.178	.022	.010	1	4
COAD	C-Raf →	+0.162	+3.178	.024	.010	3	2
UCEC	ERK2 →	+0.156	+1.247	.007	.041	3	2
UCEC	Heregulin →	-0.106	-1.986	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PCNA by DHX9 expression — UCEC

Explore this box plot interactively →