DHX9

Across TCGA cell cohorts, DHX9 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,343 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DHX9-associated GO terms across cancer lineages are Mitotic DNA integrity checkpoint signaling, Mitotic G2 DNA damage checkpoint signaling, and Regulation of G2/M transition of mitotic cell cycle. Each is linked with DHX9 in more than 19 cancer types. Because this analysis shows association rather than direction, both DHX9-to-partner and partner-to-DHX9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic DNA integrity checkpoint signaling grouped by DHX9-low versus DHX9-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX9→partner) and Y-score (partner→DHX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitotic DNA integrity checkpoint signaling →	+0.108	+0.818	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Mitotic G2 DNA damage checkpoint signaling →	+0.102	+0.988	.005	.002	3	20
UPPER_AERODIGESTIVE_TRACT	Regulation of G2/M transition of mitotic cell cycle →	+0.104	+1.284	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.070	+1.013	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle phase transition →	+0.073	+0.937	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Regulation of cell cycle G2/M phase transition →	+0.097	+1.277	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,343 associations by consensus.

Mitotic DNA integrity checkpoint signaling by DHX9 expression — BONE

Explore this box plot interactively →