DHX9

Across TCGA cell cohorts, DHX9 mutation is significantly associated with the RNA expression of many other genes, with 509 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DHX9-associated genes across cancer lineages are OR1L3, SMCP, and SPRR4. Each is linked with DHX9 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX9-to-partner and partner-to-DHX9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by DHX9-low versus DHX9-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX9→partner) and Y-score (partner→DHX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.019	+5.415	<.001	.004	3	2
BREAST	SMCP →	+0.051	+5.169	<.001	.005	3	1
BREAST	SPRR4 →	+1.092	+5.169	<.001	.005	3	1
BREAST	LCE2C →	+0.602	+5.169	<.001	.005	3	1
BLOOD_Leukemia	C1QL2 →	+0.019	+4.922	<.001	.009	3	1
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 509 associations by consensus.

OR1L3 by DHX9 expression — SKIN

Explore this box plot interactively →