DHX8

Across TCGA pan-cancer cohorts, DHX8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DHX8 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DHX8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DHX8 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

HNSC, COAD, and LUAD are the cancer types where DHX8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.783	0.925	.013	16	view →
COAD	DFS	Median	II,III,IV	1.000	0.891	.038	12	view →
LUAD	DFS	Median	II,III,IV	1.000	0.798	.015	7	view →
PDAC	DFS	Median	III,IV	0.213	0.497	.023	6	view →
GBM	DFS	Median	All	0.287	0.449	.028	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DHX8–HNSC (OS)

Open the HNSC breakdown →