DHX8

Across TCGA patient cohorts, DHX8 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,707 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DHX8-associated proteins across cancer lineages are SF3B3, XPO1, and DHX9. Each is linked with DHX8 in more than 5 cancer types. Because this analysis shows association rather than direction, both DHX8-to-partner and partner-to-DHX8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DHX8 versus SF3B3 in GBM, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX8→partner) and Y-score (partner→DHX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SF3B3 →	+0.279	+0.361	<.001	<.001	3	6
LSCC	XPO1 →	+0.338	+0.647	<.001	<.001	3	6
LSCC	DHX9 →	+0.314	+0.705	<.001	<.001	3	6
LSCC	LIG3 →	+0.585	+0.683	<.001	<.001	3	6
LSCC	LUC7L3 →	+0.252	+0.570	<.001	<.001	3	6
GBM	STAG2 →	+0.275	+0.223	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,707 associations by consensus.

DHX8 vs SF3B3 — GBM

Explore this scatter interactively →