DHX8

Across TCGA patient cohorts, DHX8 protein abundance is significantly associated with the RNA expression of many other genes, with 19,602 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DHX8-associated genes across cancer lineages are AATF, NUP85, and EME1. Each is linked with DHX8 in more than 8 cancer types. Because this analysis shows association rather than direction, both DHX8-to-partner and partner-to-DHX8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DHX8 versus AATF in HNSC, with a Pearson correlation of 0.22.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX8→partner) and Y-score (partner→DHX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AATF →	+0.650	+0.152	.007	.003	3	9
UCEC	NUP85 →	+0.532	+0.154	<.001	.001	3	8
LSCC	EME1 →	+1.029	+0.453	<.001	<.001	3	8
LSCC	ATAD5 →	+1.166	+0.433	<.001	<.001	3	8
LSCC	CDC6 →	+0.988	+0.421	<.001	<.001	3	8
HNSC	VRK1 →	+0.910	+0.173	.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,602 associations by consensus.

DHX8 vs AATF — HNSC

Explore this scatter interactively →