DHX8

Across TCGA cell cohorts, DHX8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,311 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DHX8-associated GO terms across cancer lineages are Nuclear export, Nucleocytoplasmic transport, and Heterochromatin organization. Each is linked with DHX8 in more than 15 cancer types. Because this analysis shows association rather than direction, both DHX8-to-partner and partner-to-DHX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear export grouped by DHX8-low versus DHX8-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX8→partner) and Y-score (partner→DHX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Nuclear export →	+0.130	+0.879	<.001	<.001	3	16
STOMACH	Nucleocytoplasmic transport →	+0.098	+0.775	<.001	.001	3	16
SOFT_TISSUE	Heterochromatin organization →	+0.078	+0.770	<.001	<.001	3	15
STOMACH	Heterochromatin formation →	+0.068	+0.657	<.001	<.001	3	15
SOFT_TISSUE	Epigenetic regulation of gene expression →	+0.068	+0.810	<.001	<.001	3	15
STOMACH	Negative regulation of gene expression, epigenetic →	+0.064	+0.549	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,311 associations by consensus.

Nuclear export by DHX8 expression — STOMACH

Explore this box plot interactively →