DHX38

Across TCGA patient cohorts, DHX38 mutation is significantly associated with the RNA expression of many other genes, with 3,980 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX38-associated genes across cancer lineages are LINC02841, TRAJ57, and TRAJ52. Each is linked with DHX38 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHX38-to-partner and partner-to-DHX38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02841 grouped by DHX38-low versus DHX38-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX38→partner) and Y-score (partner→DHX38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	LINC02841 →	+0.152	+6.363	<.001	.001	3	3
UCEC	TRAJ57 →	+0.325	+1.640	<.001	.002	3	3
UCEC	TRAJ52 →	+0.488	+1.586	<.001	<.001	3	3
BLCA	RN7SL248P →	+0.172	+5.033	<.001	.003	3	2
BRCA	RNU6-746P →	+0.185	+7.471	<.001	.008	3	2
BRCA	LINC00354 →	+0.325	+5.347	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,980 associations by consensus.

LINC02841 by DHX38 expression — LGG

Explore this box plot interactively →