DHX37

Across TCGA pan-cancer cohorts, DHX37 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated DHX37 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher DHX37 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DHX37 expression acts as an unfavorable survival marker, although some lineages such as BLCA and HNSC show a favorable association.

THYM, BLCA, and STAD are the cancer types where DHX37 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
BLCA	DFS	Median	All	1.000	0.319	.002	31	view →
STAD	OS	Median	All	0.143	0.672	<.001	18	view →
KIRC	OS	Median	All	0.202	0.631	.004	17	view →
BRCA	OS	Median	III,IV	0.211	0.833	<.001	12	view →
PCPG	DFS	Median	All	0.080	0.768	<.001	6	view →
READ	DFS	Median	II,III,IV	0.112	0.800	.002	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LIHC	OS	Median	All	0.105	0.774	.002	5	view →
HNSC	DFS	Median	IV	0.868	0.314	.038	2	view →
LUAD	OS	Median	All	0.446	0.703	.038	2	view →
UCEC	OS	Median	II,III,IV	0.922	0.463	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

DHX37–THYM (OS)

Open the THYM breakdown →