DHX37

Across TCGA pan-cancer cohorts, DHX37 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DHX37 data layer compared with 25 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DHX37 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DHX37 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and COAD are the cancer types where DHX37 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.805	0.247	.001	54	view →
LSCC	DFS	Median	II,III,IV	0.921	0.490	<.001	41	view →
COAD	DFS	Median	All	1.000	0.917	.022	36	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
CCRCC	DFS	Quartile	III,IV	0.717	1.000	.011	9	view →
GBM	OS	Tertile	All	0.498	0.264	.002	6	view →
HNSC	OS	Median	II,III,IV	1.000	0.954	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DHX37–LUAD (DFS)

Open the LUAD breakdown →