DHX37

Across TCGA patient cohorts, DHX37 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX37-associated genes across cancer lineages are mTOR_pS2448, eEF2, and C-Raf. Each is linked with DHX37 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHX37-to-partner and partner-to-DHX37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by DHX37-low versus DHX37-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX37→partner) and Y-score (partner→DHX37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.144	-2.302	.001	<.001	3	3
BLCA	eEF2 →	+0.398	+3.017	.002	.019	3	2
BLCA	C-Raf →	+0.335	+3.012	.001	.018	3	2
UCEC	eIF4E →	+0.131	+1.713	.037	.024	3	2
UCEC	PCNA →	+0.192	+2.502	.002	.001	3	2
UCEC	ATM →	-0.666	-1.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

mTOR_pS2448 by DHX37 expression — UCEC

Explore this box plot interactively →