DHX37

Across TCGA cell cohorts, DHX37 mutation is significantly associated with the RNA expression of many other genes, with 889 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DHX37-associated genes across cancer lineages are PDHA2, UCP1, and COQ5. Each is linked with DHX37 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHX37-to-partner and partner-to-DHX37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDHA2 grouped by DHX37-low versus DHX37-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX37→partner) and Y-score (partner→DHX37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PDHA2 →	+0.025	+4.977	<.001	.002	3	2
SKIN	UCP1 →	+0.134	+4.006	.001	.002	3	2
LARGE_INTESTINE	COQ5 →	+0.448	+2.743	.005	.001	3	2
LARGE_INTESTINE	ULBP1 →	+0.953	+2.043	<.001	.008	3	2
LARGE_INTESTINE	GOT1 →	+0.585	+2.043	.003	.008	3	2
BLOOD_Leukemia	C12orf57 →	+1.338	+3.215	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 889 associations by consensus.

PDHA2 by DHX37 expression — SOFT_TISSUE

Explore this box plot interactively →