DHX35

Across TCGA cell cohorts, DHX35 mutation is significantly associated with the RNA expression of many other genes, with 171 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DHX35-associated genes across cancer lineages are OR7E24, KRTAP5-4, and OOSP4A. Each is linked with DHX35 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX35-to-partner and partner-to-DHX35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7E24 grouped by DHX35-low versus DHX35-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX35→partner) and Y-score (partner→DHX35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR7E24 →	+0.029	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRTAP5-4 →	+0.032	+5.369	<.001	.004	3	1
SOFT_TISSUE	OOSP4A →	+0.053	+4.930	<.001	.008	3	1
LARGE_INTESTINE	RBM23 →	+0.517	+3.064	.006	.009	3	1
LARGE_INTESTINE	ZNF500 →	+0.674	+3.451	.001	.002	3	1
LARGE_INTESTINE	STMN2 →	+0.759	+2.472	.009	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 171 associations by consensus.

OR7E24 by DHX35 expression — SOFT_TISSUE

Explore this box plot interactively →