Across TCGA pan-cancer cohorts, DHX33-DT RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of DHX33-DT’s most consistent transcriptional readouts.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where DHX33-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DHX33-DT is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
UCEC and KIRC are the cancer types where DHX33-DT tumor–normal differential expression is most reproducible.