DHX30

Across TCGA patient cohorts, DHX30 mutation is significantly associated with the RNA expression of many other genes, with 5,039 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX30-associated genes across cancer lineages are PPM1D, MCAT, and MTHFD1. Each is linked with DHX30 in more than 3 cancer types. Because this analysis shows association rather than direction, both DHX30-to-partner and partner-to-DHX30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPM1D grouped by DHX30-low versus DHX30-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX30→partner) and Y-score (partner→DHX30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPM1D →	+0.361	+1.755	<.001	<.001	3	4
COAD	MCAT →	+0.345	+2.375	.006	.003	3	3
UCEC	MTHFD1 →	+0.450	+2.480	<.001	<.001	3	3
COAD	PSMC1 →	+0.373	+2.710	.001	.003	3	3
COAD	PSMA6 →	+0.483	+3.595	<.001	.001	3	3
COAD	DNAJC5 →	-0.522	-2.973	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,039 associations by consensus.

PPM1D by DHX30 expression — UCEC

Explore this box plot interactively →