DHX30

Across TCGA pan-cancer cohorts, DHX30 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DHX30’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DHX30 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DHX30 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

COAD, LIHC, and KIRC are the cancer types where DHX30 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHX30 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.125	<.001	11	view →
LIHC	Female	II,III,IV	+1.211	<.001	9	view →
KIRC	Male	II,III,IV	−0.540	<.001	7	view →
HNSC	Male	All	+0.414	.001	7	view →
BLCA	All	All	+0.410	.004	7	view →
CHOL	Male	All	+1.603	<.001	5	view →
STAD	Male	II,III,IV	+1.002	<.001	5	view →
KICH	All	All	−0.525	.002	3	view →
KIRP	Female	II,III,IV	+0.479	.013	3	view →
UCEC	All	III,IV	+0.497	.005	2	view →
READ	All	All	+0.486	.006	2	view →
ESCA	All	All	+0.475	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DHX30–COAD

Open the COAD breakdown →