DHX15

Across TCGA pan-cancer cohorts, DHX15 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DHX15 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DHX15 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DHX15 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where DHX15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.380	1.000	.008	35	view →
CCRCC	DFS	Median	II,III,IV	0.730	0.481	.012	33	view →
UCEC	OS	Median	III,IV	1.000	0.312	.003	24	view →
COAD	DFS	Tertile	IV	0.432	0.944	.038	12	view →
PDAC	DFS	Tertile	II,III,IV	0.315	0.520	.010	8	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.816	.011	7	view →
LUAD	DFS	Quartile	III,IV	0.993	0.264	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DHX15–HNSC (OS)

Open the HNSC breakdown →