DHX15

Across TCGA patient cohorts, DHX15 mutation is significantly associated with the RNA expression of many other genes, with 4,268 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX15-associated genes across cancer lineages are PAPLN, GRPEL1, and ECHS1. Each is linked with DHX15 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHX15-to-partner and partner-to-DHX15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAPLN grouped by DHX15-low versus DHX15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX15→partner) and Y-score (partner→DHX15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAPLN →	-0.694	-2.662	<.001	<.001	3	3
UCEC	GRPEL1 →	+0.502	+2.584	<.001	<.001	3	3
UCEC	ECHS1 →	+0.319	+2.294	.005	<.001	3	3
UCEC	CEP85 →	+0.473	+2.201	<.001	.001	3	3
UCEC	CEP55 →	+0.662	+3.000	<.001	<.001	3	3
UCEC	SHCBP1 →	+0.706	+2.294	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,268 associations by consensus.

PAPLN by DHX15 expression — UCEC

Explore this box plot interactively →