DHX15

Across TCGA patient cohorts, DHX15 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX15-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and ATM. Each is linked with DHX15 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHX15-to-partner and partner-to-DHX15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DHX15-low versus DHX15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX15→partner) and Y-score (partner→DHX15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.430	+1.434	.021	.027	3	3
COAD	ASNS →	+0.862	+3.178	<.001	.010	3	2
COAD	ATM →	-0.733	-3.161	<.001	.019	3	2
UCEC	GAPDH →	+0.336	+1.807	.047	.024	3	2
UCEC	C-Raf →	+0.182	+2.874	<.001	<.001	3	2
COAD	FASN →	+0.666	+3.178	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by DHX15 expression — UCEC

Explore this box plot interactively →