DHRS9

Across TCGA patient cohorts, DHRS9 mutation is significantly associated with the RNA expression of many other genes, with 919 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS9-associated genes across cancer lineages are ECEL1P3, SPANXN2, and OR8G1. Each is linked with DHRS9 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS9-to-partner and partner-to-DHRS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECEL1P3 grouped by DHRS9-low versus DHRS9-high in ACC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS9→partner) and Y-score (partner→DHRS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	ECEL1P3 →	+0.075	+5.662	<.001	.002	3	2
CESC	SPANXN2 →	+0.043	+5.569	<.001	.002	3	2
LUSC	OR8G1 →	+0.158	+5.370	<.001	.001	3	2
LUSC	LINC01947 →	+0.487	+4.684	<.001	.004	3	2
SKCM	PHB →	+0.522	+3.331	.002	.005	3	2
SKCM	CRK →	+0.605	+3.331	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 919 associations by consensus.

ECEL1P3 by DHRS9 expression — ACC

Explore this box plot interactively →