DHRS9

Across TCGA pan-cancer cohorts, DHRS9 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of DHRS9’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DHRS9 RNA is repressed in tumor relative to normal tissue. In most cancer types DHRS9 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, KIRC, and KIRP are the cancer types where DHRS9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHRS9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−3.925	<.001	11	view →
KIRC	Male	II,III,IV	+1.133	<.001	11	view →
KIRP	All	All	+1.177	<.001	7	view →
THCA	Male	All	+1.117	.002	7	view →
READ	All	All	−4.375	<.001	5	view →
BRCA	All	II,III,IV	−0.635	<.001	4	view →
HNSC	Female	III,IV	−1.916	.028	3	view →
LUSC	Male	III,IV	−1.022	.010	3	view →
UCEC	All	All	−0.699	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

DHRS9–COAD

Open the COAD breakdown →