DHRS9

Across TCGA patient cohorts, DHRS9 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS9-associated genes across cancer lineages are Caspase-8, Cyclin-B1, and p62 Lck ligand. Each is linked with DHRS9 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS9-to-partner and partner-to-DHRS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by DHRS9-low versus DHRS9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS9→partner) and Y-score (partner→DHRS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.412	-3.295	.001	.009	3	2
UCEC	Cyclin-B1 →	+0.765	+3.321	.009	.010	3	1
UCEC	p62 Lck ligand →	+0.552	+2.817	.001	.036	2	1
UCEC	TFRC →	+0.880	+3.000	.001	.036	2	1
UCEC	Tuberin →	+0.445	+3.321	.001	.010	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Caspase-8 by DHRS9 expression — UCEC

Explore this box plot interactively →