DHRS7B

Across TCGA cell cohorts, DHRS7B mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DHRS7B-associated genes across cancer lineages are ZCCHC2, ATP5F1A, and TMSB4Y. Each is linked with DHRS7B in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS7B-to-partner and partner-to-DHRS7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZCCHC2 grouped by DHRS7B-low versus DHRS7B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS7B→partner) and Y-score (partner→DHRS7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZCCHC2 →	+0.930	+3.067	.001	.009	3	1
LARGE_INTESTINE	ATP5F1A →	+0.913	+3.082	.001	.007	3	1
LARGE_INTESTINE	TMSB4Y →	+1.180	+2.819	<.001	.006	3	1
LARGE_INTESTINE	EOMES →	+0.614	+3.302	<.001	.008	3	1
LARGE_INTESTINE	CALHM6 →	+0.236	+3.626	.007	.003	3	1
LARGE_INTESTINE	PFN3 →	+0.079	+2.560	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ZCCHC2 by DHRS7B expression — LARGE_INTESTINE

Explore this box plot interactively →