DHRS7B

Across TCGA pan-cancer cohorts, DHRS7B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DHRS7B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where DHRS7B RNA is repressed in tumor relative to normal tissue. In most cancer types DHRS7B is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LIHC, and LUSC are the cancer types where DHRS7B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHRS7B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.554	<.001	11	view →
LIHC	Female	II,III,IV	+0.957	<.001	9	view →
LUSC	Male	II,III,IV	−0.754	<.001	7	view →
THCA	Male	IV	−0.809	<.001	6	view →
LUAD	All	II,III,IV	−0.367	<.001	6	view →
BRCA	Female	II,III,IV	−0.295	<.001	6	view →
STAD	Male	All	+0.328	.020	5	view →
CHOL	All	All	+1.851	<.001	3	view →
KIRC	Female	IV	+0.438	.006	1	view →
KIRP	All	II,III,IV	+0.317	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DHRS7B–KICH

Open the KICH breakdown →