DHRS7

Across TCGA pan-cancer cohorts, DHRS7 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DHRS7 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DHRS7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DHRS7 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, HNSC, and GBM are the cancer types where DHRS7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.558	0.908	.006	14	view →
HNSC	DFS	Median	IV	0.805	0.564	.021	9	view →
GBM	DFS	Median	All	0.244	0.494	.003	8	view →
PDAC	DFS	Tertile	All	0.665	0.793	.038	4	view →
LUAD	DFS	Median	III,IV	0.306	0.693	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DHRS7–LSCC (DFS)

Open the LSCC breakdown →