DHRS4

Across TCGA patient cohorts, DHRS4 protein abundance is significantly associated with the RNA expression of many other genes, with 6,989 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DHRS4-associated genes across cancer lineages are DHRS4L2, DHRS4-AS1, and AP4S1. Each is linked with DHRS4 in more than 9 cancer types. Because this analysis shows association rather than direction, both DHRS4-to-partner and partner-to-DHRS4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DHRS4 versus DHRS4L2 in UCEC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS4→partner) and Y-score (partner→DHRS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DHRS4L2 →	+0.704	+0.545	<.001	<.001	3	10
COAD	DHRS4-AS1 →	+0.665	+0.565	.001	<.001	3	6
HNSC	AP4S1 →	+0.641	+0.473	<.001	<.001	3	4
OV	PCK2 →	+0.821	+0.599	<.001	<.001	3	4
BRCA	HOMEZ →	+0.486	+0.427	<.001	<.001	3	4
BRCA	KCTD17 →	-0.434	-0.378	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,989 associations by consensus.

DHRS4 vs DHRS4L2 — UCEC

Explore this scatter interactively →