DHRS2

Across TCGA patient cohorts, DHRS2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS2-associated genes across cancer lineages are Caspase-8, c-Met_pY1235, and A-Raf_pS299. Each is linked with DHRS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS2-to-partner and partner-to-DHRS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by DHRS2-low versus DHRS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS2→partner) and Y-score (partner→DHRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.306	-3.673	.005	.001	3	2
SKCM	c-Met_pY1235 →	+0.106	+3.169	.020	.019	3	1
UCEC	A-Raf_pS299 →	-0.159	-2.999	.002	.035	3	1
UCEC	JNK2 →	+0.355	+3.486	<.001	.002	3	1
UCEC	MEK1 →	+0.440	+3.321	.005	.009	3	1
UCEC	p62 Lck ligand →	+0.349	+2.807	.014	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-8 by DHRS2 expression — UCEC

Explore this box plot interactively →