DHRS2

Across TCGA pan-cancer cohorts, DHRS2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DHRS2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DHRS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DHRS2 is over-expressed in tumor, although a few such as KIRC and PRAD show the opposite, repressed pattern.

COAD, KICH, and KIRC are the cancer types where DHRS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHRS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+1.011	<.001	11	view →
KICH	Female	II,III,IV	+5.165	<.001	8	view →
KIRC	All	II,III,IV	−0.435	<.001	7	view →
THCA	Male	All	+0.375	<.001	6	view →
HNSC	All	All	+0.684	.014	5	view →
LUSC	Male	II,III,IV	+1.245	<.001	4	view →
BRCA	All	All	+0.836	.017	4	view →
STAD	All	All	+0.834	.017	2	view →
PRAD	All	All	−0.513	.003	2	view →
LIHC	Male	All	+1.347	.019	1	view →
READ	All	All	+0.551	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DHRS2–COAD

Open the COAD breakdown →