DHRS13

Across TCGA patient cohorts, DHRS13 mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS13-associated genes across cancer lineages are FAM243A, RN7SKP246, and LINC01076. Each is linked with DHRS13 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS13-to-partner and partner-to-DHRS13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM243A grouped by DHRS13-low versus DHRS13-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS13→partner) and Y-score (partner→DHRS13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FAM243A →	+0.105	+6.733	<.001	<.001	3	2
BRCA	RN7SKP246 →	+0.132	+5.786	.007	.001	3	1
BRCA	LINC01076 →	+0.337	+5.231	<.001	.001	3	1
BRCA	ZNF70P1 →	+0.083	+4.926	<.001	.005	3	1
BRCA	USP17L10 →	+0.024	+6.725	<.001	<.001	3	1
BRCA	PTGER4P3 →	+0.183	+4.924	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

FAM243A by DHRS13 expression — LUSC

Explore this box plot interactively →