DHRS13

Across TCGA patient cohorts, DHRS13 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS13-associated genes across cancer lineages are E-Cadherin, ER-alpha, and Acetyl-a-Tubulin-Lys40. Each is linked with DHRS13 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS13-to-partner and partner-to-DHRS13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E-Cadherin grouped by DHRS13-low versus DHRS13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS13→partner) and Y-score (partner→DHRS13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	E-Cadherin →	+0.574	+3.000	.041	.037	2	1
UCEC	ER-alpha →	+1.054	+3.000	.026	.037	1	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.659	+3.000	.025	.037	1	1
UCEC	Src_pY416 →	-0.313	-2.986	.024	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

E-Cadherin by DHRS13 expression — UCEC

Explore this box plot interactively →